Zinc abuse. an unsuspected cause of sideroblastic anemia

ID de revista: PMC1002314

PMID: 2400417

Autor principal: Forman WB

Revista: West J Med

Año: 1990

Plataforma de Búsqueda: PubMed

Metodología: Reporte de caso

Grupo de estudio: Adultos


SIDEROBLASTIC ANEMIAS are disorders ofthe bone marrow in which a characteristic accumulation of iron occurs in the early erythrocyte precursors. This accumulation develops around the nucleus, forming a ringed structure known as the ringed sideroblast. The abnormality is often associated with severe irreversible diseases of the bone marrow such as the myelodysplastic disorders and leukemia.’ A few disorders do not forecast such an ominous outcome as they are reversible by either treatment or withdrawal of the offending agent. Most reversible sideroblastic anemias are caused by drugs such as isoniazid and alcohol. The patient whose case is reported here, in an attempt to “control his anger,” ingested massive amounts of elemental zinc, 1 to 2 grams per day, over a several-month period, which led to the development of a sideroblastic anemia. The nature ofhis disorder was only determined by asking specific dietary questions relating to vitamin and mineral intake. This information was not volunteered by the patient during the routine initial history. We report his case and describe the pathophysiology ofzinc toxicity and its treatment.


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